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Chih-Yang Huang Selected Research

Arecoline (Arecolin)

2/2022Arecoline induces cardiotoxicity by upregulating and activating cardiac hypertrophy-related pathways in Sprague-Dawley rats.
8/2021Arecoline induces heart injure via Fas/Fas ligand apoptotic pathway in heart of Sprague-Dawley rat.
1/2021The molecular mechanisms underlying arecoline-induced cardiac fibrosis in rats.
6/2019Taiwanin C elicits apoptosis in arecoline and 4-nitroquinoline-1-oxide-induced oral squamous cell carcinoma cells and hinders proliferation via epidermal growth factor receptor/PI3K suppression.
1/2019Taiwanin E Induces Cell Cycle Arrest and Apoptosis in Arecoline/4-NQO-Induced Oral Cancer Cells Through Modulation of the ERK Signaling Pathway.
1/2017Down-regulation of β-catenin and the associated migration ability by Taiwanin C in arecoline and 4-NQO-induced oral cancer cells via GSK-3β activation.
1/2017Taiwanin C selectively inhibits arecoline and 4-NQO-induced oral cancer cell proliferation via ERK1/2 inactivation.
12/2016Helioxanthin suppresses the cross talk of COX-2/PGE2 and EGFR/ERK pathway to inhibit Arecoline-induced Oral Cancer Cell (T28) proliferation and blocks tumor growth in xenografted nude mice.
4/2013MALDI-TOF mass spectrometry analysis of small molecular weight compounds (under 10 KDa) as biomarkers of rat hearts undergoing arecoline challenge.

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Chih-Yang Huang Research Topics

Disease

97Neoplasms (Cancer)
07/2022 - 09/2005
66Hypertrophy
09/2022 - 01/2002
63Cardiomegaly (Heart Hypertrophy)
07/2022 - 11/2004
56Fibrosis (Cirrhosis)
08/2022 - 10/2005
41Hypoxia (Hypoxemia)
01/2022 - 01/2007
34Inflammation (Inflammations)
09/2022 - 05/2006
33Hepatocellular Carcinoma (Hepatoma)
01/2022 - 09/2005
30Neoplasm Metastasis (Metastasis)
01/2022 - 09/2006
27Hypertension (High Blood Pressure)
09/2022 - 01/2004
19Heart Failure
09/2022 - 05/2006
19Cardiovascular Diseases (Cardiovascular Disease)
05/2022 - 10/2009
17Cardiomyopathies (Cardiomyopathy)
09/2021 - 01/2011
17Heart Diseases (Heart Disease)
01/2021 - 10/2005
15Body Weight (Weight, Body)
07/2022 - 10/2005
14Colorectal Neoplasms (Colorectal Cancer)
05/2022 - 04/2006
13Obesity
12/2021 - 10/2007
13Colonic Neoplasms (Colon Cancer)
10/2021 - 04/2006
12Cardiotoxicity
02/2022 - 09/2016
12Carcinogenesis
12/2019 - 05/2007
11Squamous Cell Carcinoma of Head and Neck
06/2019 - 11/2009
10Mouth Neoplasms (Oral Cancer)
06/2019 - 12/2007
9Hyperglycemia
08/2022 - 09/2015
9Myocardial Infarction
06/2019 - 12/2007
8Mitochondrial Diseases (Mitochondrial Disease)
12/2021 - 01/2013
8Breast Neoplasms (Breast Cancer)
07/2021 - 06/2004
8Prostatic Neoplasms (Prostate Cancer)
01/2019 - 05/2011
7Wounds and Injuries (Trauma)
01/2022 - 01/2016
7Diabetic Cardiomyopathies
12/2021 - 01/2011
7Diabetes Mellitus
01/2021 - 02/2014
7Osteosarcoma (Osteogenic Sarcoma)
05/2020 - 04/2005
7Hyperlipidemias (Hyperlipidemia)
01/2019 - 06/2011
7Ischemia
04/2018 - 06/2010
6Lung Neoplasms (Lung Cancer)
01/2022 - 05/2008
6Necrosis
04/2017 - 03/2007
5Parkinson Disease (Parkinson's Disease)
09/2022 - 03/2013

Drug/Important Bio-Agent (IBA)

91Proteins (Proteins, Gene)FDA Link
09/2022 - 02/2002
22Atrial Natriuretic Factor (ANF)IBA
07/2022 - 11/2004
22Matrix Metalloproteinases (MMPs)IBA
07/2022 - 06/2004
22Insulin-Like Growth Factor II (Somatomedin A)IBA
12/2021 - 01/2002
21CalcineurinIBA
07/2022 - 12/2005
21Glucose (Dextrose)FDA LinkGeneric
01/2022 - 07/2008
19Angiotensin IIIBA
09/2022 - 07/2006
16Insulin-Like PeptidesIBA
10/2021 - 01/2002
15CollagenIBA
10/2022 - 01/2011
15AntioxidantsIBA
08/2022 - 02/2010
15Estrogen ReceptorsIBA
10/2020 - 07/2006
14Brain Natriuretic Peptide (Natrecor)FDA Link
09/2022 - 05/2008
14Insulin-Like Growth Factor I (IGF-1)IBA
06/2017 - 02/2002
13Doxorubicin (Adriamycin)FDA LinkGeneric
07/2022 - 09/2016
12Caspase 3 (Caspase-3)IBA
09/2022 - 04/2008
12Pharmaceutical PreparationsIBA
01/2022 - 01/2013
12Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2022 - 02/2007
11CholesterolIBA
09/2022 - 12/2007
11EnzymesIBA
08/2022 - 06/2004
11Phosphotransferases (Kinase)IBA
12/2021 - 05/2009
11CateninsIBA
09/2019 - 08/2011
11Messenger RNA (mRNA)IBA
07/2017 - 08/2006
10Estrogens (Estrogen)FDA Link
01/2018 - 09/2006
9Sirtuin 1IBA
07/2022 - 01/2018
9neferineIBA
07/2022 - 12/2015
9Arecoline (Arecolin)IBA
02/2022 - 04/2013
9Mitogen-Activated Protein KinasesIBA
02/2022 - 04/2005
9Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA
01/2022 - 05/2008
9Reactive Oxygen Species (Oxygen Radicals)IBA
12/2021 - 11/2014
9Streptozocin (Streptozotocin)FDA Link
09/2021 - 01/2011
9Death Domain ReceptorsIBA
08/2021 - 10/2005
9Insulin (Novolin)FDA Link
01/2021 - 06/2002
8Antineoplastic Agents (Antineoplastics)IBA
12/2022 - 04/2014
8Protein Kinases (Protein Kinase)IBA
02/2022 - 04/2005
8IGF Type 2 Receptor (Insulin-Like-Growth-Factor II Receptor)IBA
12/2021 - 07/2006
8transcription factor NF-AT c3IBA
09/2021 - 08/2012
8Transcription Factors (Transcription Factor)IBA
01/2021 - 06/2008
8p38 Mitogen-Activated Protein KinasesIBA
09/2019 - 03/2007
7Caspase 9IBA
09/2022 - 08/2006
7Advanced Glycation End ProductsIBA
08/2022 - 08/2017
7Caspase 8 (Caspase-8)IBA
01/2022 - 04/2008
7ResveratrolIBA
01/2021 - 01/2016
7Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
12/2019 - 12/2005
7Interleukin-6 (Interleukin 6)IBA
01/2019 - 12/2010
7Protein Kinase C-alphaIBA
09/2016 - 09/2005
7LipidsIBA
10/2015 - 04/2006
6oxidized low density lipoproteinIBA
09/2022 - 12/2007
6CytokinesIBA
08/2022 - 05/2009
6Protein Kinase CIBA
02/2022 - 09/2005
6Hematoxylin (Haematoxylon)IBA
01/2022 - 10/2007
6Eosine Yellowish-(YS) (Eosin)IBA
01/2022 - 10/2007
6Histone Deacetylase InhibitorsIBA
01/2022 - 01/2014
6LigandsIBA
12/2021 - 04/2006
6TeaIBA
02/2021 - 03/2014
6Isoproterenol (Isoprenaline)FDA LinkGeneric
01/2021 - 01/2016
6Therapeutic UsesIBA
01/2021 - 01/2012
6Plasminogen Activators (Plasminogen Activator)IBA
06/2019 - 05/2009
6Urokinase-Type Plasminogen Activator (Urokinase)FDA Link
06/2019 - 05/2009
6Dinoprostone (PGE2)FDA Link
12/2018 - 09/2010
6Tobacco Smoke Pollution (Passive Smoking)IBA
09/2016 - 10/2005

Therapy/Procedure

38Therapeutics
12/2022 - 04/2006
13Drug Therapy (Chemotherapy)
01/2022 - 02/2012
9Chinese Traditional Medicine (Traditional Chinese Medicine)
05/2022 - 10/2009
8Oral Administration
07/2021 - 02/2010
6Transplantation
01/2022 - 11/2017